Formation development and evolution of oral fast disintegrating film of zolmitriptan
Abstract
The main aim of the present study was to develop oral fast disintegrating film of Zolmitriptan for the treatment of migraine. Oral fast disintegrating films were prepared by HPMC E5 as a polymer, ipropylene iglycol ias an iplasticizer, isodium istarch iglycolate is a super disintegrant, and aspartame it is a sweetener. optimization was done by using the i23 factorial design. iThe optimized batch was prepared by using i4% of HPMC iE5, i1.5 i% of ipropylene iglycol, and i4% of isodium istarch iglycolate. It gave disintegration time I of I 9 sec, drug release of i98.15%, and folding endurance of i200 times. from the above research work it is concluded that oral fast disintegrating film of Zolmitriptan was successfully designed and developed by solvent casting method and it gives quick onset of action, patient compliance
Keywords:
Zolmitriptan, HPMC, solvent casting method
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References
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2. Patel Priti, Patel Jaymin, Patel Kaushika, Nihar Shah ShahShreeraj. A review on oral fast dissolving sublingual films. J.Pharm.Sci.Bio.Sci.Res. 2015; 5(3): 279-285
3. Deepak Heer, GeetaAggarwal and S.L. Hari Kumar. Recent trends of fast dissolving drug delivery systems- An overview of formulation technology. Pharmacophore. 2013; 4(1): 1-9
4. Swapnil iL. iPatil, iParesh iR. iMahaparale, iMadhavi iA. iShivnikar, iSharadha iS. iTiwari, iKetan iv. iPawar, iPrasant iN. iSane, iFast iDissolving iOral iFilms: iAn iInnovative iDrug iDelivery iSystem, iIJRPAS, i2(3).482-496.
5. RajniBala, iPravinPawar, iSushilKhanna, iSandeepArora. iA inew iapproach ito ioral idrug idelivery isystem. iJornal iof ipharmacy. i2015: i117.206.233.149.
6. BharadwajNishant, iBuccal iMucosa: iA iNovelistic iRoute iof iDrug iDelivery, iInternational iJournal iOf iPharmaceutical iAnd iChemical iSciences, iVol. i1 i(3) iJul-Sep i2012.
7. NAziyaKhatoon, iN. iG. iRaghavendra iRo, iB. iMahipal iReddy, iOverview iOn iFast iDissolving iOral iFilms, iInternational iJournal iof ichemistry iand iPharmaceutical iSciences i2013, iVol. i1(1) i: i63-75.
8. Nikunjbhura, iA iReview iOn iFast iDissolving iFilm,IJPRBS,2012: ivolume i1 i(3):66-89.
9. Kunte iS, iTandale ip. iFast idissolving istrips: iA inovel iapproach ifor ithe idelivery iof iverapamil. iJ.pharm.Bilall.Sci. i2010; i4: i325-8.,
10. A.Deepthi, iB. iVenkateswara iReddy, iand iK. iNavaneetha. iFormulation iand ievaluation iof ifast idissolving ioral ifilms iof izolmitriptan. iAJADD. i2014; i2(2): i153-163.
11. Kapoor iD1, iVyas iRB1, iLad iC1, iPatel iM1, iTyagi iBL2Frabrication iand icharacterization iof ioral ithin ifilms iof ileukotriene ireceptor iantagonist i(LTRA).Journal iof iDrug iDelivery i& iTherapeutics. i2015; i5(2):77-82.
12. Farhana isultana, iMohammad iArafat, iSaiful iI iPathan. iPreparation iand ievaluation iof ifast idissolving ioral ifilm iof icaffeine. iIJPBS. i2013; i3(1): i153-161.
13. Aggarwaljyothi, iJindal ikhesav, iSingh igrupreet. iFormulation iand ievaluation iof ioral ifast idissolving ifilms iof iGranisetron ihydrochloride iusing idifferent ipolymers. iIRJP.2015; i6(10): i724-728.
14. Vijayakuchana, DeepthiKammila, SumathiSampathi, PamuSandhya, Amareshwar S. Preparation and invitro evaluation of buclizine oral thin film strips. IJPIR. 2014; 4(2):63-68.
15. Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian Journal of Research in Pharmaceutical Science. 2017;7(2):97-104.
16. Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian Journal of Pharmacy and Technology. 2017;7(3):137-43.
17. Babu AK, Teja NB, Ramakrishna B, Kumar BB, Reddy GV. Formulation and evaluation of double walled microspheres loaded with pantoprazole. METHODS. 2011;15:28.
18. Babu AK, Reddy VR, Reddy N, Vidyasagar J. Evaluating the post compression parameter of ibuprofen by using super disintegrants. An Int J Adv Pharm Sci. 2010;1(2):247-53.
19. Aruna MS, Babu AK, Thadanki M, Gupta ME. Solid dispersions–an approach to enhance the dissolution rate of Irbesartan. IJRPC. 2011;1(4):780-7.
20. Babu K, Ramana MV. Development and in vivo evaluation of gastro retentive floating tablets of antipsychotic drug risperidone. Int J Pharm Pharm Sci. 2016;11:43-52.
21. Babu AK, Ramana MV. In Vitro and In Vivo Evaluation of Quetiapine Fumarate controlled gastroretentive floating drug delivery system.
Published
21/01/2022
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How to Cite
[1]
S. N. N, V. J. P. Marabathuni, and N. Narapusetty, “Formation development and evolution of oral fast disintegrating film of zolmitriptan”, Int J Indig Herb Drug, vol. 7, no. 1, pp. 01-07, Jan. 2022.
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