Study on drug utilization evaluation of anti epileptic drugs

2023-05-14T02:00:48+0530

INTRODUCTION: Drug utilization evaluation (DUE) also referred as drug utilization reviews (DUR) or medication utilization evaluation (MUE) are defined as an authorized, structured, ongoing review of healthcare provider prescribing, pharmacist dispensing, and patient use of medication. Anti-epileptic drugs (AEDs) are those which are used for epilepsy and also for other neurological disorders. METHODOLOGY: A prospective observational questionnaire based cross sectional study in 200 patients of various departments receiving at least one AEDs. The subjects were included in the study only after they met the criteria for the study and after properly filling a informed consent form. The data was obtained by a questionnaire format and it is evaluated for utilization patterns, medication adherence. The cost of AEDs were calculated to evaluate total costs on each drug. RESULTS: Out of 200 patients, 140 were male and 60 were female. The age group 11- 20 years were found prominent with epilepsy. The average number of AEDs per patient was found to be 1.54. Among all the drugs prescribed phenytoin was the most common drug prescribed 148 (47.89%) for the treatment, followed by lorazepam 59 (19.09 %) and sodium valproate 27 (8.73 %). Maximum of the patients are high in utilization patterns and also in medication adherence. The chi-square value was 1.1373 and 1.3886 for medication adherence and utilization patterns respectively. CONCLUSION: Medication adherence was also high in patients which was found using morisky medication adherence scale. The utilization pattern was also 82 % by the patients. The cost effectiveness was done by comparing the costs of drugs prescribed during the study. It was found that topiramate is having high cost which can be burden to patient to adhere the therapy.

A Yoga-based pulmonary rehabilitation for the management of Chronic obstructive pulmonary disease: A Randomized controlled trial

2023-05-16T11:52:05+0530

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and health care use. COPD -Chronic obstructive pulmonary Disease (COPD), a common preventable and treatable disease, is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to the noxious particles or gases. Objectives: To evaluate the effectiveness of Yoga Therapy in the management of dyspnea and fatigue in patients with COPD. Inclusion criteria: 1. Age > 18 years. 2. History, examination and PFT consistent with COPD as per GOLD guidelines. PFT showing: -FEV1/FVC < 0.70 -irreversible bronchial obstructions (<12% and /or <200ml increase in FEV1 or FVC, 20 minutes after the administration of 200μg of inhaled salbutamol). Exclusion criteria: 1. History of acute respiratory tract infection in the past 4 weeks prior to study. 2. History of medication with antibiotics and /or steriods (oral, injection or inhalation) in the previous 4 weeks prior to study. 3. Patients with cardiovascular disease, diabetes mellitus, Neuro -masculo-skeletal deficits, tuberculosis, hepatic or renal diseases. 4. Pregnant and lactating females. 5. History of thyroid disorders, parathyroid disorder and thyroidectomy. Materials and methods: A randomised controlled trial at New Delhi India hospital a Tertiary care unit:Sixty COPD patients (18 to 60years) ,both male and female were recruited. The yoga group received an intervention Yoga module for COPD that included asanas, loosening practices, breathing practices, pranayama, meditation, yogic counseling and lectures 45 min/day, 3days/weeks on alternate days for 12 weeks. Primary and secondary outcomes: Measurements of dyspnea and fatigue on the spirometry, exercise capacity by the 6 min walk test, COPD QUESSIONAIRE, and C –Reactive protein (CRP) for inflammatory response were made before and after the intervention.Results: Statistically significant within group reductions in dyspnea (P <0.001), COPD quessionaire (P <0.001) scores, CRP (P <0.001), and 6 min walk distance (P <0.001) were observed in the yoga group; all except the last were significant compared to controls (P <0.001). Conclusions: Findings indicate that yoga benefits patients with COPD. Yoga can now be included as an adjunct to conventional therapy for pulmonary rehabilitation to most cases of COPD can be prevented by Yoga programs for COPD patients.

International Journal of Alternative and Complementary Medicine

Study on drug utilization evaluation of anti epileptic drugs

A Yoga-based pulmonary rehabilitation for the management of Chronic obstructive pulmonary disease: A Randomized controlled trial