A review of analytical techniques for determination of metformin: present and perspectives

  • Anil Kumar Tallam Department of pharmacy,Shri Venkateshwara University,Rajabpur, NH-24, Venkateshwara Nagar, Gajraula, Uttar Pradesh 244236
  • Alapati Sahithi Assistant Professor, Department of Pharmaceutical Analysis,Nalla Narasimha Reddy Education Society's Group of Institutions,Narapally, Ghatkesar Mandal, Korremula Rd, Hyderabad, Telangana 500088
  • Mohana Vamsi Nuli Associate Professor,Raghavendra Institute of Pharmaceutical Education and ResearchK.R. Palli Cross, Dist Anantapuramu, Chiyyedu, Andhra Pradesh 515721


Metformin is an oral anti-diabetic drug in preventing complications of type 2 diabetes and it is a good first-line therapy for an over-obese with type 2 diabetes, it is currently available in more than 60 countries worldwide. As a result of the importance of this oral hypoglycaemic agent in the treatment of non-insulin-dependent diabetes mellitus, which leads to end-stage renal disease, this work aims to compile the published analytical methods reported so far in the literature for the determination in biological samples and pharmaceutical formulations. This article narrates different techniques like high-performance liquid chromatography. It can be seen that high-performance liquid chromatography methods have been used extensively. Thus, this paper will help in the selection and development of proper analytical methodologies estimation of Metformin to achieve satisfactory results.

Keywords: Analytical methods, Metformin, HPLC, Chromatography


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How to Cite
Tallam, A. K., S. Alapati, and M. V. Nuli. “A Review of Analytical Techniques for Determination of Metformin: Present and Perspectives”. International Journal of Health Care and Biological Sciences, Vol. 4, no. 1, Feb. 2023, pp. 18-24, doi:10.46795/ijhcbs.v4i1.417.
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