International Journal of Health Care and Biological Sciences https://www.saap.org.in/journals/index.php/ijhcbs <p>International Journal of Health Care and Biological Sciences (IJHCBS) is an international online open access, peer-reviewed, quarterly journal Publish Health as well as Life sciences field on the basis of its originality, and serve as a means for scientific information exchange in the international Health Care and Biological science with a strong emphasis on originality and scientific quality. IJHCBS aims to publish quarterly and accepts for publishing original and research articles, review articles, case studies, and reports short communication, meta-analysis.</p> International Journal of Health Care and Biological Sciences en-US International Journal of Health Care and Biological Sciences 2582-7499 Development and Validation of New Analytical Method for The Simultaneous Estimation of Levodropropizine And Chlorpheniramine In Pharmaceutical Dosage Form https://www.saap.org.in/journals/index.php/ijhcbs/article/view/159 <p>A simple, Accurate, precise method was developed for the simultaneous estimation of the Levodropropizine and Chlorpheniramine in Tablet dosage form. The chromatogram was run through Ascentis C18 150 x 4.6 mm, 5m. Mobile phase containing Buffer Kh2po4: Acetonitrile was taken in the ratio 40:60was pumped through the column at a flow rate of 1.0ml/min. The buffer used in this method was Kh2po4. The temperature was maintained at 30°C. The optimized wavelength selected was260nm. The retention time of Levodropropizine and Chlorpheniramine was found to be 2.276min and 2.848. %RSD of the Levodropropizine and Chlorpheniramine was and found to be 0.7 and 0.7 respectively. %Recovery was obtained as 100.73% and 99.03% for Levodropropizine and Chlorpheniramine respectively. LOD, LOQ values obtained from regression equations of Levodropropizine and Chlorpheniramine were 0.14, 0.02, and 0.43, 0.06 respectively. Regression equation of Levodropropizine is y = 67089x + 5956.8 and y = 226526x + 13941 of Chlorpheniramine. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control tests in Industries.&nbsp;&nbsp;</p> Vepa Vishnu Vardhan Reddy P.Sreenivasa Prasanna K. Thejomoorthy Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2021-05-18 2021-05-18 33 42 10.46795/ijhcbs.vi.159 Formulation and Invitro Characterization of Fluvoxamine Loaded Nanoparticles https://www.saap.org.in/journals/index.php/ijhcbs/article/view/160 <p>Fluvoxamine is an antidepressant that functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. As the biological half-life of the drug is 15.6 hrs and belongs to BCS class II. To overcome these problems, Nanoparticles of Fluvoxamine were formulated by using Ethyl Cellulose, Eudragit RS 100 &amp; Eudragit Rl 100 as a polymer by emulsification method. Among all the 9 formulations F6 formulation is optimized, as it shows maximum drug release at the end of 12hrs which suits the controlled release drug delivery system criteria as per our studies, having acceptable particle size, SEM, and Zeta potential value. From the drug release kinetics of the F8 formulation of Losartan Nanoparticles dispersion, it was concluded that the F8 formulation follows Zero-order drug release with super case II transport mechanism.</p> Naga Durga Mani Achyuth S. V Ch.Saibabu T.Malyadri Copyright (c) 2021 https://creativecommons.org/licenses/by-nc/4.0 2021-05-31 2021-05-31 43 52 10.46795/ijhcbs.vi.160