International Journal of Health Care and Biological Sciences https://www.saap.org.in/journals/index.php/ijhcbs <p>International Journal of Health Care and Biological Sciences (IJHCBS) is an international online open access, peer-reviewed, quarterly journal Publish Health as well as Life sciences field on the basis of its originality, and serve as a means for scientific information exchange in the international Health Care and Biological science with a strong emphasis on originality and scientific quality. IJHCBS aims to publish quarterly and accepts for publishing original and research articles, review articles, case studies, and reports short communication, meta-analysis.</p> en-US editor@ijhcbs.com (Editor in Chief) editorijhcbs@gmail.com (Support Manager) Fri, 16 Jul 2021 12:45:56 +0530 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 Brief review on remdesivir https://www.saap.org.in/journals/index.php/ijhcbs/article/view/222 <p>Remdesivir is an investigational broad-spectrum small-molecule antiviral drug that has confirmed interest in the direction of RNA viruses in numerous families, which encompass Coronaviridae (alongside aspect SARS-CoV, MERS-CoV, and lines of bat coronaviruses able to infecting human respiratory epithelial cells), Paramyxoviridae (alongside aspect Nipah virus, respiratory syncytial virus, and Hendra virus), and Filoviridae (alongside aspect Ebola virus). Originally superior to cope with Ebola virus infection , remdesivir is a prodrug of the determine adenosine analog, each of which can be metabolized into an energetic nucleoside triphosphate (NTP) via the host. The determine nucleoside, GS-441524, has displayed antiviral interest within the direction of SARS-CoV, Marburg virus , and pussycat infectious peritonitis virus, amongst others. A fashion of research have tested the effects of these pills on coronaviruses (CoVs) each in vitro and in vivo the use of mouse and non-human primate animal models.</p> Venkata Niharika Daka, Lakshmi Sravanthi Bandi , Sushma Alla, Venkata Spandana Cheedella, Sadasiva Rao Galaba Copyright (c) 2021 Daka Venkata Niharika https://creativecommons.org/licenses/by-nc/4.0 https://www.saap.org.in/journals/index.php/ijhcbs/article/view/222 Sun, 25 Jul 2021 00:00:00 +0530 A case report on pemphigus foliaceus https://www.saap.org.in/journals/index.php/ijhcbs/article/view/207 <p>Pemphigus Foliaceus (PF) is second most common autoimmune vesicular disease in the pemphigus family characterized by superficial blisters of the skin and rarely mucous membranes which rupture to produce scaly, crusted lesions. A 54 year old female patient admitted in female derma ward in tertiary care hospital, with the chief complaints of painful ruptured blisters all over the body with crusty, scaly patches associated with serous discharge and itching since 15 days. A positive Nikolsky’s sign is when the skin shears off easily when the surface is wiped sideways with a cotton swab or a finger. Based on both subjective and objective evidence, this case is assessed as Pemphigus Foliaceus. The plan incudes Corticosteroids, Immunosuppressants, Antibiotics, Vitamin A &amp; D supplements, IV fluids, calcium and aminoacids supplements, antivirals and antifungals (if needed), proper wound management and finally plasmapheresis.&nbsp;&nbsp;&nbsp;</p> Divyasree Muppineni, Vishnu Sree Uppu, Dr.Firoz Shaik Copyright (c) 2021 Divyasree Muppineni, Vishnu Sree Uppu, Dr.Firoz Shaik https://creativecommons.org/licenses/by-nc/4.0 https://www.saap.org.in/journals/index.php/ijhcbs/article/view/207 Thu, 22 Jul 2021 00:00:00 +0530