International Journal of Health Care and Biological Sciences <p>International Journal of Health Care and Biological Sciences (IJHCBS) is an international online open access, peer-reviewed, quarterly journal Publish Health as well as Life sciences field on the basis of its originality, and serve as a means for scientific information exchange in the international Health Care and Biological science with a strong emphasis on originality and scientific quality. IJHCBS aims to publish quarterly and accepts for publishing original and research articles, review articles, case studies, and reports short communication, meta-analysis.</p> en-US (Editor in Chief) (Support Manager) Tue, 23 Feb 2021 20:47:37 +0530 OJS 60 Nanosuspension formulation & evaluation of ritonavir & valsartan by using poloxamer as a stabilizing agent to enhance the oral bio availability <p>The Nano ionization technology is particularly promising for improving&nbsp; the oral&nbsp; absorption and bioavailability of BCS class II drugs. One such approach is Nano ionization&nbsp; thereby increasing&nbsp; surface&nbsp; area&nbsp; and hence dissolution and ultimately the bioavailability. Ritonavir is a BCS class II and IV drug. Valsartan is a commonly used antihypertensive agent belonging to the family of angiotensin II receptor antagonists. Valsartan is a BCS class II drug being slightly soluble in water. It has a very low oral bioavailability of 25-35% due to its limited solubility in biological fluids.&nbsp; Poor water solubility of drugs shows insufficient bioavailability and fluctuating plasmalevels. Based on their physicochemical and biopharmaceutical properties, Ritonavir and Valsartan were&nbsp; selected&nbsp;&nbsp; as&nbsp;&nbsp; a&nbsp;&nbsp; drug&nbsp;&nbsp; candidates&nbsp;&nbsp; for&nbsp;&nbsp;&nbsp; developing&nbsp;&nbsp;&nbsp; Nanosuspension&nbsp; based&nbsp;&nbsp;&nbsp; formulations for improving the solubility and bioavailability&nbsp;&nbsp;&nbsp; by&nbsp;&nbsp;&nbsp; enhancing the rate and extent ofdissolution.The scope of the present work is to enhance the solubility, dissolution rate and oral bio availability of poorly soluble drugs Ritonavir and Valsartan by formulating them into Nanosuspension with Poloxamer as a stabilizing agent and&nbsp; subsequently&nbsp; converting&nbsp; the optimized Nanosuspension of Ritonavir/Valsartan drug molecule into tablets and capsuleswith the help of various extragranular agents.</p> Sudhakar Kancharla, Prachetha Kolli, Dr.K.Venkata Gopaiah Copyright (c) 2021 Fri, 05 Mar 2021 00:00:00 +0530 Assessment of depression by using beck’s depression inventory <p>Depression is an mental disorder that associated with depressed mood ,loss of pleasure,loss of interest over any work. There is an immediate need for awareness programs and counselling and educate the depressed people in the social and psychological environment. If there is any delay in conducting these awareness programs, this may impact on the delayed activities which may effect their carrier. This is a review which gives a calculated report of Beck’s depression inventory scale ,which is utilized for the calibration of levels of depression in a group lo students of age 17-25 years. It is an prospective observational study conducted on 328 individuals (N=328) to depict the levels of their handling stress.Infect that this present article gives review report.</p> G.S.S.S.N.Pravallika, R.Bindu Rasagna``, K.Emmanielu, Dr.Sd.Abdul Jabbar Basha, Dr.Venkata Ramana Copyright (c) 2021 Tue, 09 Mar 2021 00:00:00 +0530 Green tea; Best way to struggle lipid <p>Introduction: Tea is one of the most common famous drink used daily in many countries in the world. Green tea contains polyphenolic compounds as catechins, that contains epigallocatechin gallate (EGCG). The lowering of plasma cholesterol levels and blood pressure as well as improvement of insulin sensitivity and endothelial function by green tea. Aim of the work: Study the effect of green tea on obesity, blood lipid level and its effect on fatty liver. Materials and Methods: All animal procedures were approved by the ethical committee of Faculty of Medicine, Tanta University. Thirty male Albino rats in the range of 230–280 g body weight was used in this study. All subjects were kept in an animal room of Physiology Department of Faculty of Medicine, Tanta University, in a controlled temperature and 12:12 h light/dark cycle with free access to food and water. The animals were divided into 3 groups of 10 animals each. Group-1: the sham group (sham operated, no obesity). Group-2: the vehicle group (obesity induced rats treated with normal saline). Group-3: the ghrelin group (obesity induced rats treated with EGCG). Results: Body weight, fat deposits, adiposity index and serum cholesterol increased significantly in a time-dependent manner in obese and control animals but were higher in the obese group (HFD &gt; SD). High fat diet caused significant increases in the serum cholesterol level indicating high body lipid and obesity but when EGCG was administered after the beginning of high fat diet, these elevations were significantly depressed. Conclusion: In conclusion, since the administration of EGCG increase lipolysis and the accumulation of neutrophils in the damaged hepatic tissue, this agent appears to play a cytoprotective role in the liver insulted by fatty infiltration with obesity. It seems likely that Green tea (EGCG) is put in consideration as a potential therapeutic agent against obesity and hyperlipidemia.</p> Mohamed F. Madi, Fouad Ibrahim, Ahmed G. Elsayed, Laila M. Elgendy, Elsayed A. Emara, Salima Hawda Copyright (c) 2021 Wed, 10 Mar 2021 00:00:00 +0530 Interstitium: New Shock Absorbers in Human Body <p>Agroup of fluid-filled compartments researchers has termed the "interstitium". This looks like a mesh with the network of skin, gut, lungs, blood vessels, and muscles with a strong flexible protein. The interstitium is the largest organ of the body which has been unnoticed.The teams of the invention say that compartments may act as “shock absorbers” that protect body tissues from damage.They realized the interstitium layer drains into the lymphatic system which may also spread cancer as a noticed side effect – the network of vessels transporting lymph, which is involved in the body’s immune response and providing a way for fluid to move around the body.</p> Dr.Sd. Abdul Jabbar Basha, Dr.K.Venkata Ramana, Nagalakshmi Copyright (c) 2021 Tue, 23 Feb 2021 00:00:00 +0530 Review article on sleep apnea <p>Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that involves a reduces or complete halt in airflow despite an ongoing effort to breathe. It occurs when the muscles relax during sleep, causing soft tissue in the back of the throat to collapse and block the upper airway. This results in partial reductions (hypopneas) and complete block (apneas) in breathing that lasts a minimum of 10 seconds during sleep. Most pauses last between 10 and 30 seconds, but some may persist for one minute or longer. This can cause abrupt reductions in blood oxygen saturation. The brain responds to the lack of oxygen by alerting the body, causing a brief arousal from sleep that restores normal breathing. This pattern can occur many times in one night. The result is a fragmented quality of sleep that often produces an excessive level of daytime sleepiness. Most people with OSA snore loudly and regullarly, with periods of silence when airflow is reduced or blocked. They then make choking, snorting or gasping sounds when their airway reopens. A common measurement of sleep apnea is the apnea-hypopnea index (AHI).</p> Simhavalli.Godavarthi, B. Pravallika, B. Tushara, L. Krishnapriya Copyright (c) 2021 Sat, 06 Feb 2021 00:00:00 +0530