Formulation development and stability studies of bilayer tablets of linagliptin and metformin

  • Ch.Saibabu Head , Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • R.Raviteja Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101.


In vitro release studies were carried out by USP type 2 paddle apparatus. The results showed that Eudragit’s in a sustained layer can control the release of drugs. The in vitro release profile of the drug from the sustained-release layer could be expressed by Higuchi's equation as the pilot shows high linearity R2 =0.9911and diffusion was the dominant mechanism of drug release. The formulation (F6) having an immediate-release layer produces an immediate effect of 93.53 ± 0.30 within 45 minutes followed by a sustained release effect of 94.77 ± 0.37 up to 8 hours. The present study concluded that Bilayer tablets of Lingaptin and Metformin HCl can be a better alternative to conventional dosage forms for providing sustained drug delivery.

Keywords: Bilayer tablet, linagliptin, Metformin HCl, Sustained Release, Higuchi equation


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Ch, S., & R, R. (2021). Formulation development and stability studies of bilayer tablets of linagliptin and metformin. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 08-14. Retrieved from
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