Formulation development and stability studies of bilayer tablets of linagliptin and metformin

  • Ch.Saibabu Head , Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
    saichennupalli@gmail.com
  • R.Raviteja Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101.

Abstract

In vitro release studies were carried out by USP type 2 paddle apparatus. The results showed that Eudragit’s in a sustained layer can control the release of drugs. The in vitro release profile of the drug from the sustained-release layer could be expressed by Higuchi's equation as the pilot shows high linearity R2 =0.9911and diffusion was the dominant mechanism of drug release. The formulation (F6) having an immediate-release layer produces an immediate effect of 93.53 ± 0.30 within 45 minutes followed by a sustained release effect of 94.77 ± 0.37 up to 8 hours. The present study concluded that Bilayer tablets of Lingaptin and Metformin HCl can be a better alternative to conventional dosage forms for providing sustained drug delivery.

Keywords: Bilayer tablet, linagliptin, Metformin HCl, Sustained Release, Higuchi equation

References

Lambert P (2002). What is Type 1 Diabetes. (1)5:1383.

Giuseppe D, Sibilla A (2007). Pioglitazone and Metformin fixed‐dose combination in type 2 diabetes mellitus: an evidence‐based review of its place in therapy. Department of Internal Medicine and Therapeutics, University of Pavia, Italy. 2(3), 189‐198.

Jitendra R. Amrutkar, Mohan. G.Kalaskar, Varsha. G. Shrivastav, P.G. Yeole (2009). Bilayer tablet formulation of metformin hydrochloride and gliclazide: A novel approach in the treatment of diabetes. International Journal of Pharma Research and development. 1, 1‐11.

Defang Y (2005). Formulation and evaluation of bi-layer tablets of Metformin Hcl and Glipizide.Pharm.res. 16;1748-1756

Giovanna C, Marzia C, Francesca M, Natascia M, Paola M (2007). Sustained release matrix tablets of metformin hydrochloride in combination with triacetyl beta cyclodextrin. Eur J Pharm Biopharm. 1-7.

Ritu D, Rajat G, Harsha P, Pradeep l, Bharat D (2009). Formulation and Characterization of Sustained Release Matrix Tablet of Metformin Hydrochloride . Int J Pharm Recent Res. 1(1): 49- 53.

Jain NK (2006). Pharmaceutical product development. 1sted. Delhi: CBS Publication and Distribution.423-425

Howida k, Ahmed M (2010). Biopharmaceutical evaluation of formulated Metformin Hcl tablets. Drug Discoveries & Thera. 4(2): 100-108.

Dolat R, Guruviah A(2010) . Formulation and evaluation of bilayered sustained release matrix tablets of Metformin HCl Sr and Pioglitazone. Ame Eur J Sci Res. 5(3): 176-82.

Rajendran R, Natarajan R, Subhasini R, Patel H (2011). Formulation and evaluation of sustained release bilayer of metformin hcl and pioglitazone hcl. Int J pharm res. 3(3):118-122. 11. Hosties E (1986). Handbook of Pharmaceutical Excipients Published by American Pharmaceutical Association and the Pharmaceutical Society of Great Britain, 321-324.

Choi J (2000). Formulation and evaluation of double layer tablet of terfenadine and pseudoephedrine. J. Contr .Rel. 102:569-581.

Maggi D (1999). Formulation and evaluation of biphasic release tablets of ketoprofen and praziquantel. Pharm.Res. 16:1149-1155.

Dandagi P, Mastiholimath V (2005). Development and evaluation of theophylline and Salbutamol sulphate sustained release matrix Tablets. Ind. J. Pharm. Sci. 67 (5): 598-602.

Subhas H (2011) .Formulation evaluation of metformin hydrochloride and glimepiride: A novel approach to improve therapeutic efficacy. 1(1):1- 4.

Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian J Res Pharm Sci. 2017 Jun 28;7:97-104.

Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian Journal of Pharmacy and Technology. 2017;7(3):137-43.
Published
30/04/2021
Statistics
21 Views | 3 Downloads
Citatons
How to Cite
Ch, S., & R, R. (2021). Formulation development and stability studies of bilayer tablets of linagliptin and metformin. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 08-14. Retrieved from https://www.saap.org.in/journals/index.php/jiaps/article/view/210
Section
Research Article(S)