Formulation and optimization of synthetic polymer based herbal emulgel for anti-microbial activity
The aim of the present research was to develop and evaluate the anti-microbial emulgel by using three different types of synthetic polymers. The active moiety selected for the formulation was the seeds of Carica papaya fruit. The formulation was developed by performing the extraction process; Soxhlet extraction with ethanol and water. The seeds of Carica papaya are reported to have anti-microbial properties. The skin-friendly i.e., the topical formulation was selected for development. Emulgel was prepared by incorporating different polymers and then evaluating each of them for best results. Basic evaluation parameters such as organoleptic parameters, viscosity, consistency, pH, homogeneity have been done, which demonstrate the results as per the reference and standard articles. Along with that, qualitative and quantitative tests of Carica seeds have also been performed, which indicates that the selected plant material is safe for usage. Finally, the most imp test, the anti-microbial test has been performed for determining the efficacy of prepared emulgel. Hence, it can be concluded that the prepared emulgel is safe and best for topical use as an anti-microbial.
2. Shokri J, Azarmi S, Fasihi Z: Effect of various penetration enhancers on percutaneous absorption of piroxicam from emulgel. Res. Pharm. Sci.2012; 7: 225–2234.
3. Adeneye AA, Olagunja JA. Preliminary hypoglycemic andhypolipidemic activities of aqueous seed extract of Carica papaya Linn in Wistar rats. Biol Med. 2009; 1:1-10.
4. Alabi, OA., Haruna, MT., Anokwuru, CP., Jegede, T., Abia, H., Okegbe, V. and Esan, E. 2012.Comparative studies on antimicrobial properties of extracts of fresh and dried leaves of Carica papaya (L) on clinical bacterial and fungal isolates. Pelagia Research Library. 3 (5):3107-3114.
5. Aravind. G, Debjit B, Duraivel. S, Harish. G. 2013. Traditional and Medicinal Uses of Carica papaya. Journal of Medicinal Plants Studies. 1(1): 7-15.
6. Ahmad I and Beg A 2001 Antimicrobial and phytochemicals studies on 45 indian medicinal plants against multidrug resistant human pathogens Ethnopharm. 74(87) pp 113-23.
7. Latha S and Kannabiran K 2006 Antimicrobial activity and phytochemicals of Solanum Trinobatum Linn. Afr. J. Biotechnol. 5(23) pp 2402–4.
8. Pretorius C and Walt E 2001 Purification and identification of active compound of Carpobrotusedulis L. J. Ethnopharn. 76 pp 87–91.
9. Mulyono Lienny M 2013 Antibacterial activity of papaya (Carica papaya L.) seed ethanol extract against Escherichia coli and Staphylococcus aureus Jurnal Ilmiah Mahasiswa Universitas Surabaya 2(2) :pp 1-9.
10. Latha S and Kannabiran K 2006 Antimicrobial activity and phytochemicals of Solanum Trinobatum Linn. Afr. J. Biotechnol. 5(23) pp 2402–4.
11. Pretorius C and Walt E 2001 Purification and identification of active compound of Carpobrotusedulis L. J. Ethnopharn. 76 pp 87–91.
12. Mulyono Lienny M 2013 Antibacterial activity of papaya (Carica papaya L.) seed ethanol extract against Escherichia coli and Staphylococcus aureus Jurnal Ilmiah Mahasiswa Universitas Surabaya 2(2) :pp 1-9.
13. Khan, J. A., Yadav, J., Srivastava, Y., & Pal, P. K. (2012). In vitro evaluation of antimicrobial properties of Carica papaya. International Journal of Biology, Pharmacy and Allied Sciences, 1(7), 933-945.
14. Jin, Y. J., Ubonvan, T., & Kim, D. D. (2010). Hyaluronic acid in drug delivery systems. Journal of Pharmaceutical Investigation, 40(spc), 33-43.
15. Rachit, K., Arvind, G., & Geeta, A. (2011). Generic drugs–A ground discussion. Int J Drug Dev Res, 3, 178-84.
16. Panwar, A., Upadhyay, N., Bairagi, M., Gujar, S., Darwhekar, G., & Jain, D. (2011). Emulgel: a review. Asian J Pharm Life Sci, 2231, 4423.
17. Mohamed, M. I. (2004). Optimization of chlorphenesin emulgel formulation. The AAPS journal, 6(3), 81-87.
18. Haneefa, K. M., Easo, S., Hafsa, P. V., Mohanta, G. P., & Nayar, C. (2013). Emulgel: An advanced review. Journal of pharmaceutical sciences and research, 5(12), 254.
19. Alorkpa, E. J., Boadi, N. O., Badu, M., & Saah, S. A. (2016). Phytochemical screening, antimicrobial and antioxidant properties of assorted Carica papaya leaves in Ghana.
20. Tumpa, S. I., Hossain, M. I., & Ishika, T. (2015). Antimicrobial activities of Psidium guajava, Carica papaya and Mangifera indica against some gram positive and gram-negative bacteria. Journal of Pharmacognosy and Phytochemistry, 3(6), 125-129.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.