https://www.saap.org.in/journals/index.php/jiaps/issue/feed Journal of Innovations in Applied Pharmaceutical Science (JIAPS) 2021-07-25T18:40:40+0530 Support info@saap.org.in Open Journal Systems <p><span style="color: #000000;">Journal of Innovations in Applied pharmaceutical Science (JIAPS) is an open access, quarterly, peer-reviewed multi-disciplinary journal; and will publish articles in various streams of pharmaceutical &amp; allied sciences. JIAPS publishes original research and review articles, Mini-reviews, Short communication, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in the fields of applied pharmaceutics</span></p> https://www.saap.org.in/journals/index.php/jiaps/article/view/206 Formulation and evaluation of taste masking sachets containing quetiapine fumarate 2021-07-06T16:21:47+0530 Abhilash A malyapharma22@gmail.com Malyadri T malyapharma22@gmail.com Saibabu Ch malyapharma22@gmail.com <p>Quetiapine fumarate is a tetracyclic&nbsp;piperazino-azepine&nbsp;antidepressant agent. It is given with a dose of 15-45mg orally once a day. The absorption of this drug is rapid and complete.&nbsp;Due to first pass metabolism in the liver and metabolism in the gut wall, absolute bioavailability is about 50%.&nbsp;Peak blood concentrations are attained within about 2 hours after an oral dose. This leads to lower bioavailability of Quetiapine fumarate&nbsp; also having bitter taste. So to improve its bioavailability and to mask the taste solid dispersion technique was used using different carriers like&nbsp; PEG 6000, &amp; Poloxamer. Results of prepared taste masking sachets by solid dispersion technique of Quetiapine fumarate&nbsp; by Fusion method &amp; kneading method were discussed which includes solubility, drug content uniformity, and <em>in vitro </em>dissolution studies.&nbsp; Characterization in solid state was done by FT-IR studies. Finally by comparing all the formulations i.e., F1-F12 containing Quetiapine fumarate, Poloxamer and PEG 6000 in different ratios, <em>Invitro</em> drug release of Quetiapine fumarate with PEG 6000 in 1:3 by Fusion method shows 98.62% drug release at the end of 60mins. By comparing the release kinetics studies of best formulation of Quetiapine fumarate with zero order and first order we can say that the best formulation follows Zero order release kinetics studies.</p> 2021-04-30T00:00:00+0530 Copyright (c) 2021 https://www.saap.org.in/journals/index.php/jiaps/article/view/210 Formulation development and stability studies of bilayer tablets of linagliptin and metformin 2021-07-25T18:40:40+0530 Saibabu Ch saichennupalli@gmail.com Raviteja R saichennupalli@gmail.com <p>In vitro release studies were carried out by USP type 2 paddle apparatus. The results showed that Eudragit’s in a sustained layer can control the release of drugs. The in vitro release profile of the drug from the sustained-release layer could be expressed by Higuchi's equation as the pilot shows high linearity R2 =0.9911and diffusion was the dominant mechanism of drug release. The formulation (F6) having an immediate-release layer produces an immediate effect of 93.53 ± 0.30 within 45 minutes followed by a sustained release effect of 94.77 ± 0.37 up to 8 hours. The present study concluded that Bilayer tablets of Lingaptin and Metformin HCl can be a better alternative to conventional dosage forms for providing sustained drug delivery.</p> 2021-04-30T00:00:00+0530 Copyright (c) 2021